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![Cardiac amyloidosis: the pathologist's point of view](https://image.oaes.cc/96af27dd-e193-474a-8b51-071e0e96f46d/4939.fig.1.jpg)
Figure 1. Endomyocardial biopsy diagnosis of cardiac amyloidosis: (A) traditional hematoxylin–eosin stain with evidence of eosinophilic interstitial deposits between cardiomyocytes; (B) Heidenhain trichrome stain highlighting amyloid in pale blue; (C,D) Congo red stain under light microscopy (C) and polarized light microscopy (D) with the typical apple-green birefringence; (E) immunohistochemical typing positive for TTR fibrils; and (F) thioflavin-T staining showing fluorescence in dark-field microscopy upon binding to amyloid fibrils. (A-F) Original magnification,× 100.