fig4

From: Perspective on the development of a bioengineered patch to treat heart failure: rationale and proposed design of phase I clinical trial

Figure 4. : Rat Diastolic Pressure-Volume Relationship; Ex vivo Pressure-Volume (P/V) diastolic filling curves of SHAM (n = 4), CHF (n = 5), and graft-treated rats (n = 7). Left ventricular volumes were normalized to each rat’s body weight. CHF results in a rightward shift in the PV filling curve and an increase in the operating volume. The graft-treated rats have a P/V filling curve shifted back towards SHAM and a lower end operating volume, consistent with reversal of maladaptive remodeling related to compliance^[18].