fig1
![Reversibility of adverse cardiac remodeling in type 2 diabetes mellitus patients: focus on sodium-glucose cotransporter-2 inhibitors](https://image.oaes.cc/f878d08c-bff1-4c1f-9813-a1e78668eae0/5224.fig.1.jpg)
Figure 1. Underlying pathogenetic mechanisms of tissue protective effects of SGLT2 inhibitors↑. Akt: Serine/threonine-specific protein kinase; HF: heart failure; CaMK: Ca2+/calmodulin-dependent protein kinase; mTOR: mammalian target of rapamycin; SGLT2: sodium-glucose cotransporter 2; PI3K: phosphatidylinositol 3-kinase; ↑: increase; ↓: decrease.