fig2

Figure 2. ADAM23 and GRIA1 (AMPA-R subtype 1) are part of a trans-synaptic protein complex that regulates synaptic excitability (A). Disruption of the protein complex with autoantibodies (B) or genetic mutation, results in hyper-excitability, seizures, and encephalopathy. Reproduced with permission from Springer/Nature Review Neurology^[42].