fig2
![A failure of forward translation? The case of neuroprotection](https://image.oaes.cc/6de3c971-53f8-46d7-bfbf-745473b1a8bc/3910.fig.2.jpg)
Figure 2. ADAM23 and GRIA1 (AMPA-R subtype 1) are part of a trans-synaptic protein complex that regulates synaptic excitability (A). Disruption of the protein complex with autoantibodies (B) or genetic mutation, results in hyper-excitability, seizures, and encephalopathy. Reproduced with permission from Springer/Nature Review Neurology[42].