fig3

Figure 3. Impact of elevated pressure levels on markers of cell activity. Isolated branches of the mesenteric vein of male NMRI mice were exposed to 4- or 16-mmHg, respectively in the presence or absence of diclofenac. Protein extracts generated from these blood vessels were analyzed by capillary electrophoresis as described above. The level of phosphorylated ERK1/2 and the abundance of MMP-2 (pro-enzyme: 72 kDa was below detection limit, active form: ~ 62 kDa) were determined; A: *P < 0.05 vs. 4 mmHg, ^#P < 0.05 vs. 16 mmHg, n = 4-5 as indicated; B: **P < 0.01 vs. 4 mmHg, ^##P < 0.01 vs. 16 mmHg, n = 3-4 as indicated.