fig3
From: Inhibition of cyclooxygenase activity by diclofenac attenuates varicose remodeling of mouse veins
![Inhibition of cyclooxygenase activity by diclofenac attenuates varicose remodeling of mouse veins](https://image.oaes.cc/2bbdf5c7-66c6-49d6-adf1-a35a8e415596/3909.fig.3.jpg)
Figure 3. Impact of elevated pressure levels on markers of cell activity. Isolated branches of the mesenteric vein of male NMRI mice were exposed to 4- or 16-mmHg, respectively in the presence or absence of diclofenac. Protein extracts generated from these blood vessels were analyzed by capillary electrophoresis as described above. The level of phosphorylated ERK1/2 and the abundance of MMP-2 (pro-enzyme: 72 kDa was below detection limit, active form: ~ 62 kDa) were determined; A: *P < 0.05 vs. 4 mmHg, #P < 0.05 vs. 16 mmHg, n = 4-5 as indicated; B: **P < 0.01 vs. 4 mmHg, ##P < 0.01 vs. 16 mmHg, n = 3-4 as indicated.