fig1

Figure 1. A model for the mechanism by which oxidative stress induces apoptosis via the autocrine secretion of eIF5A (oxidative stress-responsive apoptosis-inducing protein)^[6]. AIF: apoptosis-inducing factor; cyt c: cytochrome c; dH: deoxyhypusine; DHS: deoxyhypusine synthase; DOHH: deoxyhypusine hydroxylase; H: hypusine; Jaks: Janus kinases; S, sulfated; PARP-1: poly (ADP-ribose) polymerase-1; STATs: signal transducers and activators of transcriptions; TPST: tyrosyl protein sulfotransferase; eIF5A: eukaryotic translation initiation factor 5A