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From: Deletion of retinoic acid-related orphan receptor gamma reduces body weight and hepatic lipids in mice by modulating the expression of lipid metabolism genes

Deletion of retinoic acid-related orphan receptor gamma reduces body weight and hepatic lipids in mice by modulating the expression of lipid metabolism genes

Figure 4. Changes in hepatic expression of fatty acid metabolism genes in RORγ knockout mice. Total mRNA from the livers of WT and KO mice were used to determine the expression of fatty acid metabolism genes. Relative changes in the mRNA expression were calculated based on the expression of 18 sRNA. Values were plotted as mean ± SD. P values were calculated using two-tailed Student’s t test. *P < 0.05 and **P < 0.01. WT: wild type; KO: knockout; RORγ: retinoic acid-related orphan receptor γ; Cd36: cluster of differentiation 36; Fabp1: fatty acid binding protein 1; Fas: fatty acid synthase; Acc1a: acetyl-CoA carboxylase 1a; Acc2: acetyl-CoA carboxylase 2; Scd1: stearoyl-coenzyme A desaturase-1