fig3

Figure 3. Changes in hepatic expression of cholesterol metabolism genes in RORγ knockout mice. Total mRNA from the livers of WT and KO mice were used to determine the expression of cholesterol metabolism genes. Relative changes in the mRNA expression were calculated based on the expression of 18 sRNA. Values were plotted as mean ± SD. P values were calculated using two-tailed Student’s t test. *P < 0.05 and **P < 0.01. WT: wild type; KO: knockout; RORγ: retinoic acid-related orphan receptor γ; Hmgr: hydroxymethylglutaryl-CoA reductase; Hmgs: hydroxymethylglutaryl-CoA synthase; Abca1: ATP-binding cassette transporter A1; Abcg1: ATP-binding cassette transporter G1; Abcg5: ATP-binding cassette transporter G5; Abcg8: ATP-binding cassette transporter G8; Acat1: acetyl-CoA acetyltransferase 1; Acat2: acetyl-CoA acetyltransferase 2; Cyp7a: cholesterol 7alpha-hydroxylase