fig3
![Trigger mechanisms in insulin resistance and diabetes mellitus development](https://image.oaes.cc/31a33c80-58a8-4510-ab5a-5e3e09eeffdc/3006.fig.3.jpg)
Figure 3. Intracellular mechanisms of insulin gene transcription damage by high concentrations of glucose and fatty acids[11]. ROS: reactive oxygen radicals; PDX-1: pancreatic/duodenal homeobox-1; C/EBP β: CCAAT/enhancer binding protein β; JNK: C-jun N-terminal kinase