REFERENCES
1. Bhatnagar P, Wickramasinghe K, Wilkins E, Townsend N. Trends in the epidemiology of cardiovascular disease in the UK. Heart 2016;102:1945-52.
2. Islam AM, Mohibullah A, Paul T. Cardiovascular disease in Bangladesh: a review. Bangladesh Heart J 2016;31:80-99.
3. Ness AR, Powles JW. Fruit and vegetables, and cardiovascular disease: a review. Int J Epidemiol 1997;26:1-13.
4. Stewart J, Manmathan G, Wilkinson P. Primary prevention of cardiovascular disease: a review of contemporary guidance and literature. JRSM Cardiovasc Dis 2017;6:2048004016687211.
5. Sun LY, Lee EW, Zahra A, Park JH. Risk factors of cardiovascular disease and their related socio-economical, environmental and health behavioral factors: focused on low-middle income countries-a narrative review article. Iran J Public Health 2015;44:435-44.
8. Cecelja M, Chowienczyk P. Role of arterial stiffness in cardiovascular disease. JRSM Cardiovasc Dis 2012; doi: 10.1258/cvd.2012.012016.
9. Strait JB, Lakatta EG. Aging-associated cardiovascular changes and their relationship to heart failure. Heart Fail Clin 2012;8:143-64.
10. Ungvari Z, Kaley G, de Cabo R, Sonntag WE, Csiszar A. Mechanisms of vascular aging: new perspectives. J Gerontol A Biol Sci Med Sci 2010;65:1028-41.
11. Palombo C, Kozakova M. Arterial stiffness, atherosclerosis and cardiovascular risk: pathophysiologic mechanisms and emerging clinical indications. Vascul Pharmacol 2016;77:1-7.
13. Safar ME, Czernichow S, Blacher J. Obesity, arterial stiffness, and cardiovascular risk. J Am Soc Nephrol 2006;17:S109-11.
14. Mitchell GF, Hwang SJ, Vasan RS, Larson MG, Pencina MJ, et al. Arterial stiffness and cardiovascular events: the Framingham heart study. Circulation 2010;121:505-11.
15. Sethi S, Rivera O, Oliveros R, Chilton R. Aortic stiffness: pathophysiology, clinical implications, and approach to treatment. Integr Blood Press Control 2014;7:29-34.
17. DeLoach SS, Townsend RR. Vascular stiffness: its measurement and significance for epidemiologic and outcome studies. Clin J Am Soc Nephrol 2008;3:184-92.
18. Tsamis A, Krawiec JT, Vorp DA. Elastin and collagen fibre microstructure of the human aorta in ageing and disease: a review. J R Soc Interface 2013;10:20121004.
19. Belz GG. Elastic properties and windkessel function of the human aorta. Cardiovasc Drugs Ther 1995;9:73-83.
20. Steed MM, Tyagi N, Sen U, Schuschke DA, Joshua IG, et al. Functional consequences of the collagen/elastin switch in vascular remodeling in hyperhomocysteinemic wild-type, eNOS-/-, and iNOS-/- mice. Am J Physiol Lung Cell Mol Physiol 2010;299:L301-11.
21. Wagenseil JE, Mecham RP. Vascular extracellular matrix and arterial mechanics. Physiol Rev 2009;89:957-89.
22. Jufri NF, Mohamedali A, Avolio A, Baker MS. Mechanical stretch: physiological and pathological implications for human vascular endothelial cells. Vasc Cell 2015;7:8.
23. Humphrey JD. Mechanisms of arterial remodeling in hypertension: coupled roles of wall shear and intramural stress. Hypertension 2008;52:195-200.
24. Ye GJ, Nesmith AP, Parker KK. The role of mechanotransduction on vascular smooth muscle myocytes cytoskeleton and contractile function. Anat Rec (Hoboken) 2014;297:1758-69.
25. Sehgel NL, Vatner SF, Meininger GA. “Smooth muscle cell stiffness syndrome”-revisiting the structural basis of arterial stiffness. Front Physiol 2015;6:335.
26. Qiu H, Zhu Y, Sun Z, Trzeciakowski JP, Gansner M, et al. Short communication: vascular smooth muscle cell stiffness as a mechanism for increased aortic stiffness with aging. Circ Res 2010;107:615-9.
27. Haga JH, Li YS, Chien S. Molecular basis of the effects of mechanical stretch on vascular smooth muscle cells. J Biomech 2007;40:947-60.
28. Brozovich FV, Nicholson CJ, Degen CV, Gao YZ, Aggarwal M, et al. Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders. Pharmacol Rev 2016;68:476-532.
29. Alexander MR, Owens GK. Epigenetic control of smooth muscle cell differentiation and phenotypic switching in vascular development and disease. Annu Rev Physiol 2012;74:13-40.
30. Owens GK. Molecular control of vascular smooth muscle cell differentiation and phenotypic plasticity. Novartis Found Symp 2007;283:174-91.
31. Yamin R, Morgan KG. Deciphering actin cytoskeletal function in the contractile vascular smooth muscle cell. J Physiol 2012;590:4145-54.
32. Skalli O, Ropraz P, Trzeciak A, Benzonana G, Gillessen D, et al. A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation. J Cell Biol 1986;103:2787-96.
33. Papakonstanti EA, Stournaras C. Cell responses regulated by early reorganization of actin cytoskeleton. FEBS Lett 2008;582:2120-7.
34. Rzucidlo EM, Martin KA, Powell RJ. Regulation of vascular smooth muscle cell differentiation. J Vasc Surg 2007;45:A25-32.
35. Rensen SS, Doevendans PA, van Eys GJ. Regulation and characteristics of vascular smooth muscle cell phenotypic diversity. Neth Heart J 2007;15:100-8.
37. Eddinger TJ, Meer DP. Myosin II isoforms in smooth muscle: heterogeneity and function. Am J Physiol Cell Physiol 2007;293:C493-508.
38. Löfgren M, Ekblad E, Morano I, Arner A. Nonmuscle myosin motor of smooth muscle. J Gen Physiol 2003;121:301-10.
39. Woodrum DA, Brophy CM. The paradox of smooth muscle physiology. Mol Cell Endocrinol 2001;177:135-43.
40. Martinsen A, Dessy C, Morel N. Regulation of calcium channels in smooth muscle: new insights into the role of myosin light chain kinase. Channels (Austin) 2014;8:402-13.
41. Fridlyand LE, Philipson LH. Pancreatic beta cell G-protein coupled receptors and second messenger interactions: a systems biology computational analysis. PloS One 2016;11:e0152869.
42. Inagami T, Eguchi S, Tsuzuki S, Ichiki T. Angiotensin II receptors AT1 and AT2: new mechanisms of signaling and antagonistic effects of AT1 and AT2. In: Dhalla NS, Zahradka P, Dixon IMC, Beamish RE, editors. Angiotensin II receptor blockade physiological and clinical implications. Boston: Springer; 1998. pp. 129-39.
43. Walsh MP. Calmodulin and its roles in skeletal muscle function. Can Anaesth Soc J 1983;30:390-8.
44. Lee S, Kumar S. Actomyosin stress fiber mechanosensing in 2D and 3D. F1000Res 2016; doi: 10.12688/f1000research.8800.1.
45. Schwartz MA. Integrins and extracellular matrix in mechanotransduction. Cold Spring Harb Perspect Biol 2010;2:a005066.
47. Fukata Y, Amano M, Kaibuchi K. Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells. Trends Pharmacol Sci 2001;22:32-9.
48. Amano M, Nakayama M, Kaibuchi K. Rho-kinase/ROCK: a key regulator of the cytoskeleton and cell polarity. Cytoskeleton (Hoboken) 2010;67:545-54.
50. Murányi A, Derkach D, Erdodi F, Kiss A, Ito M, et al. Phosphorylation of Thr695 and Thr850 on the myosin phosphatase target subunit: inhibitory effects and occurrence in A7r5 cells. FEBS Lett 2005;579:6611-5.
51. Burute M, Thery M. Spatial segregation between cell-cell and cell-matrix adhesions. Curr Opin Cell Biol 2012;24:628-36.
52. Lodish H, Berk A, Zipursky SL, Matsudaira P, Baltimore D, et al. Cell-cell adhesion and communication. Molecular cell biology. New York: W. H. Freeman; 2000.
53. Sun Z, Parrish AR, Hill MA, Meininger GA. N-cadherin, a vascular smooth muscle cell-cell adhesion molecule: function and signaling for vasomotor control. Microcirculation 2014;21:208-18.
54. Lyon CA, Johnson JL, White S, Sala-Newby GB, George SJ. EC4, a truncation of soluble N-cadherin, reduces vascular smooth muscle cell apoptosis and markers of atherosclerotic plaque instability. Mol Ther Methods Clin Dev 2014;1:14004.
55. Lyon CA, Wadey KS, George SJ. Soluble N-cadherin: a novel inhibitor of VSMC proliferation and intimal thickening. Vascul Pharmacol 2016;78:53-62.
56. Lyon CA, Koutsouki E, Aguilera CM, Blaschuk OW, George SJ. Inhibition of N-cadherin retards smooth muscle cell migration and intimal thickening via induction of apoptosis. J Vasc Surg 2010;52:1301-9.
57. Perez TD, Nelson WJ. Cadherin adhesion: mechanisms and molecular interactions. Handb Exp Pharmacol 2004; doi: 10.1007/978-3-540-68170-0_1.
58. Shapiro L, Weis WI. Structure and biochemistry of cadherins and catenins. Cold Spring Harb Perspect Biol 2009;1:a003053.
59. Weis WI, Nelson WJ. Re-solving the cadherin-catenin-actin conundrum. J Biol Chem 2006;281:35593-7.
60. Wozniak MA, Modzelewska K, Kwong L, Keely PJ. Focal adhesion regulation of cell behavior. Biochim Biophys Acta 2004;1692:103-19.
62. Suki B, Parameswaran H, Imsirovic J, Bartolák-Suki E. Regulatory roles of fluctuation-driven mechanotransduction in cell function. Physiology (Bethesda) 2016;31:346-58.
63. Bachir AI, Zareno J, Moissoglu K, Plow EF, Gratton E, et al. Integrin-associated complexes form hierarchically with variable stoichiometry in nascent adhesions. Curr Biol 2014;24:1845-53.
64. Romer LH, Birukov KG, Garcia JG. Focal adhesions: paradigm for a signaling nexus. Circ Res 2006;98:606-16.
65. Chorev DS, Volberg T, Livne A, Eisenstein M, Martins B, et al. Conformational states during vinculin unlocking differentially regulate focal adhesion properties. Sci Rep 2018;8:2693.
66. Mierke CT. The role of vinculin in the regulation of the mechanical properties of cells. Cell Biochem Biophys 2009;53:115-26.
67. Carisey A, Ballestrem C. Vinculin, an adapter protein in control of cell adhesion signalling. Eur J Cell Biol 2011;90:157-63.
68. Burke B, Ellenberg J. Remodelling the walls of the nucleus. Nat Rev Mol Cell Biol 2002;3:487-97.
69. Warren DT, Zhang Q, Weissberg PL, Shanahan CM. Nesprins: intracellular scaffolds that maintain cell architecture and coordinate cell function? Expert Rev Mol Med 2005;7:1-15.
70. Haque F, Lloyd DJ, Smallwood DT, Dent CL, Shanahan CM, et al. SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton. Mol Cell Biol 2006;26:3738-51.
71. Crisp M, Liu Q, Roux K, Rattner JB, Shanahan C, et al. Coupling of the nucleus and cytoplasm: role of the LINC complex. J Cell Biol 2006;172:41-53.
72. Guilluy C, Osborne LD, Van Landeghem L, Sharek L, Superfine R, et al. Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus. Nat Cell Biol 2014;16:376-81.
73. Lombardi ML, Jaalouk DE, Shanahan CM, Burke B, Roux KJ, et al. The interaction between nesprins and sun proteins at the nuclear envelope is critical for force transmission between the nucleus and cytoskeleton. J Biol Chem 2011;286:26743-53.
74. Stewart RM, Zubek AE, Rosowski KA, Schreiner SM, Horsley V, et al. Nuclear-cytoskeletal linkages facilitate cross talk between the nucleus and intercellular adhesions. J Cell Biol 2015;209:403-18.
75. Chambliss AB, Khatau SB, Erdenberger N, Robinson DK, Hodzic D, et al. The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction. Sci Rep 2013;3:1087.
76. Schwartz C, Fischer M, Mamchaoui K, Bigot A, Lok T, et al. Lamins and nesprin-1 mediate inside-out mechanical coupling in muscle cell precursors through FHOD1. Sci Rep 2017;7:1253.
77. Chancellor TJ, Lee J, Thodeti CK, Lele T. Actomyosin tension exerted on the nucleus through nesprin-1 connections influences endothelial cell adhesion, migration, and cyclic strain-induced reorientation. Biophys J 2010;99:115-23.
78. Porter LJ, Holt MR, Soong D, Shanahan CM, Warren DT. Prelamin a accumulation attenuates rac1 activity and increases the intrinsic migrational persistence of aged vascular smooth muscle cells. Cells 2016; doi: 10.3390/cells5040041.
79. Thakar K, May CK, Rogers A, Carroll CW. Opposing roles for distinct LINC complexes in regulation of the small GTPase RhoA. Mol Biol Cell 2017;28:182-91.
80. Alonso JL, Goldmann WH. Cellular mechanotransduction. AIMS Biophys 2016;3:50-62.
81. Belaadi N, Aureille J, Guilluy C. Under pressure: mechanical stress management in the nucleus. Cells 2016; doi: 10.3390/cells5020027.
82. Wrighton KH. Cell adhesion: the ‘ins’ and ‘outs’ of integrin signalling. Nat Rev Mol Cell Biol 2013;14:752.
83. Anwar MA, Shalhoub J, Lim CS, Gohel MS, Davies AH. The effect of pressure-induced mechanical stretch on vascular wall differential gene expression. J Vasc Res 2012;49:463-78.
84. Ducret T, El Arrouchi J, Courtois A, Quignard JF, Marthan R, et al. Stretch-activated channels in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats. Cell calcium 2010;48:251-9.
85. Zou H, Lifshitz LM, Tuft RA, Fogarty KE, Singer JJ. Visualization of Ca2+ entry through single stretch-activated cation channels. Proc Natl Acad Sci U S A 2002;99:6404-9.
86. Humphrey JD, Harrison DG, Figueroa CA, Lacolley P, Laurent S. Central artery stiffness in hypertension and aging: a problem with cause and consequence. Circ Res 2016;118:379-81.
87. Tabas I, García-Cardeña G, Owens GK. Recent insights into the cellular biology of atherosclerosis. J Cell Biol 2015;209:13-22.
88. Kher N, Marsh JD. Pathobiology of atherosclerosis--a brief review. Semin Thromb Hemost 2004;30:665-72.
89. Tracqui P, Broisat A, Toczek J, Mesnier N, Ohayon J, et al. Mapping elasticity moduli of atherosclerotic plaque in situ via atomic force microscopy. J Struct Biol 2011;174:115-23.
90. Bennett MR, Sinha S, Owens GK. Vascular smooth muscle cells in atherosclerosis. Circ Res 2016;118:692-702.
91. Hytönen VP, Wehrle-Haller B. Mechanosensing in cell-matrix adhesions - converting tension into chemical signals. Exp Cell Res 2016;343:35-41.
92. Timraz SBH, Rezgui R, Boularaoui SM, Teo JCM. Stiffness of extracellular matrix components modulates the phenotype of human smooth muscle cells in vitro and allows for the control of properties of engineered tissues. Procedia Eng 2015;110:29-36.
93. Sazonova OV, Isenberg BC, Herrmann J, Lee KL, Purwada A, et al. Extracellular matrix presentation modulates vascular smooth muscle cell mechanotransduction. Matrix Biol 2015;41:36-43.
94. McDaniel DP, Shaw GA, Elliott JT, Bhadriraju K, Meuse C, et al. The stiffness of collagen fibrils influences vascular smooth muscle cell phenotype. Biophys J 2007;92:1759-69.
95. Chaterji S, Kim P, Choe SH, Tsui JH, Lam CH, et al. Synergistic effects of matrix nanotopography and stiffness on vascular smooth muscle cell function. Tissue Eng Part A 2014;20:2115-26.
96. Seawright JW, Sreenivasappa H, Gibbs HC, Padgham S, Shin SY, et al. Vascular smooth muscle contractile function declines with age in skeletal muscle feed arteries. Front Physiol 2018;9:856.
97. Kohn JC, Lampi MC, Reinhart-King CA. Age-related vascular stiffening: causes and consequences. Front Genet 2015;6:112.
98. Isenberg BC, Dimilla PA, Walker M, Kim S, Wong JY. Vascular smooth muscle cell durotaxis depends on substrate stiffness gradient strength. Biophys J 2009;97:1313-22.
99. Berry MF, Engler AJ, Woo YJ, Pirolli TJ, Bish LT, et al. Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance. Am J Physiol Heart Circ Physiol 2006;290:H2196-203.
100. Liu F, Tschumperlin DJ. Micro-mechanical characterization of lung tissue using atomic force microscopy. J Vis Exp 2011; doi: 10.3791/2911.
101. Lopez JI, Kang I, You WK, McDonald DM, Weaver VM. In situ force mapping of mammary gland transformation. Integr Biol (Camb) 2011;3:910-21.
102. Plodinec M, Loparic M, Monnier CA, Obermann EC, Zanetti-Dallenbach R, et al. The nanomechanical signature of breast cancer. Nat Nanotechnol 2012;7:757-65.
