fig1

Figure 1. The cellular roles of the CSC complex. The schematic diagram summarizes the known CSC interaction protein partners (interactome), defined CSC-modulated signaling pathways (signalome), and distinct molecular and cellular functions of CSC complex (vasculome) with our current understanding of CSC cellular functions. CCM: cerebral cavernous malformations; CSC: CCM signaling complex; EC: endothelial cells