fig4

Figure 4. Role of polyunsaturated fatty acids in triacylglyceride metabolism. PUFAs decrease TAG through various mechanisms: (1) competitive inhibition of DAT; (2) activating PPAR-α, which promotes the transcription of enzymes involved in lipolysis and fatty acid transport; (3) suppressing the activity of SREBP-1c which regulates the expression of genes involved in fatty acid and TAG synthesis. PUFA: polyunsaturated fatty acid; DAT: 1,2 diglyceride acyltransferase; TAG: triacylglycerides; PPAR-α: peroxisome-proliferator activated receptor alpha; RXR: retinoid X receptor; LXR-α: liver X receptor alpha; SREBP-1c: sterol regulatory element-binding protein 1c; SCAP: SREBP inhibitor protein; PPRE: PPAR response elements