fig7

Figure 7. Molecular modeling to compare the interaction between D-amino acids and L-amino acids of UIM or UPI with VEGFR2 kinase domain. The 3D models of L- and D-amino acids UIM and L- and D-amino acids UPI were predicted by the PEP-FOLD program (L-form and D-form). Stick representations of the L-form of UIM (A) and D-form of UIM (B) form mirror-images of the actual structures. In the same manner, the L-form of UPI (C) and D-form of UPI (D) form mirror-images of the actual structures. (E) Surface representation of the L-form of UPI (UIM, red; anchoring peptide and iRGD, green) interacting with VEGFR2-KD (blue). (F) In the same manner as the L-form of UPI interacts with VEGFR2-KD, surface representation shows the D-form of UPI (UIM, red; anchoring peptide and iRGD, green) binds to the same binding pocket of VEGFR2 (blue)