fig6

Figure 6. UPI-Ub-VEGFR2 KD forms a supercomplex. (A) UPI hybrid peptide (red: UIM, cyan: plasma membrane-anchoring peptide, green: tumor homing peptide) interacts with Ub (pink). (B) Supercomplex of UPI-Ub-VEGFR2. The model of UPI-Ub was docked onto VEGFR2 kinase domain (marine, PDB entry 3U6J). The UIM domain of UPI tightly binds to Ub, and the C-terminal tail of Ub (8-amino acid stretches, Gly76 side chain, magenta) inserts into the binding pocket of VEGFR2. (C) Surface representation of UPI-Ub-VEGFR2 KD supercomplex