fig3
![Mimetic peptide of ubiquitin-interacting motif of epsin as a cancer therapeutic-perspective in brain tumor therapy through regulating VEGFR2 signaling](https://image.oaes.cc/fc2c7e07-f6f4-419b-88ea-efbd77caf340/1703.fig.3.png)
Figure 3. Design of the UPI peptide. (A) Alignment of human epsin UIM, mouse epsin UIM, and yeast Vps27 UIM with UPI chimeric peptide; (B) iRGD binds integrin and goes through proteolysis. The last 4 amino acids (GPDC) will be removed by circulating proteases.[23] UPI peptide contains an epsin UIM, a PM targeting sequence from the Lyn kinase H4 domain, and a tumor homing sequence (iRGD). Figure 3 is adapted with permission from ref. 19. Copyright 2015 ASCI