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Figure 2. Loss of epsins in endothelial cells inhibits tumor growth by producing upregulated, but non-functional tumor angiogenesis. (A) LLC tumor is much smaller in EC-iDKO mice, accompanied by upregulated, but dilated vessels in tumors; (B) Vessel function assay: FITC-Dextran perfusion suggests that tumor vessels in EC-iDKO mice are hyper leaky. Scale bars = 50 µm for A and B. Figure 2 is adapted with permission from ref. 20. Copyright 2012 ASCI