fig7

Figure 7. Uptake of contrast agent (Gd-DOTA) in pancreatic tumor after administration of a vascular disrupting agent CA4P. Concentration of Gd-DOTA was obtained from pre- and post-contrast (post-CE) T1 mapping. Vascular shutdown was clearly depicted 1-h after CA4P injection, and tumor was gradually re-perfused afterwards. CA4P: combretastatin A4 phosphate; Gd-DOTA: gadolinium-tetraazacyclododecane tetraacetic acid