fig6

Figure 6. Quantitative relaxation mapping (A and B) and diffusion images (C and D) in rat orthotopic pancreatic tumor model. The tumor was treated with a vascular disrupting agent CA4P. After 7-h of CA4P intervention, acute hemorrhagic necrosis (arrow) resulted in a decreased T2 and diffusion kurtosis. At 24-h after treatment, intra-tumoral hemorrhage was absorbed, a necrosis core (arrow) was detected in areas with increased T2 and ADC value. CA4P: combretastatin A4 phosphate; ADC: apparent diffusion coefficient