fig1

Figure 1. Microglia signalling pathways involving AD risk genes. (A) Key signalling pathways in microglia involving AD risk genes (microglia enriched highlighted in blue, other AD risk genes, purple); (B) signalling converging on the Wave Regulatory Complex (WRC) can impact cytoskeletal polymerisation/depolymerisation to inhibit lamellipodia capping and promote formation of filopodia for cell sensing (homeostatic microglia) or promote lamellipodia capping which promotes phagocytosis in response to damage/pathogen signals (activated microglia).