fig1

Figure 1. Retinal and optic nerve inflammation during the course of experimental autoimmune encephalomyelitis. Baseline: continuously layered retinal ganglion cells in the retina, well-structured myelinated axons in the optic nerve, resting microglia, and astrocytes. Early-stage and peak of disease: microglia and astrocyte activation, macrophage polarization, T-cell infiltration. Axonal demyelination, swelling, early degeneration. Late-stage: microgliosis, astrogliosis, T cell infiltration, axonal loss, and demyelination