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![What is the role of Brain derived neurotrophic factor in Multiple Sclerosis neuroinflammation?](https://image.oaes.cc/3aa8876a-c758-4655-b25e-032536469a1a/3599.fig.1.jpg)
Figure 1. Intracellular signaling cascades induced by interaction of mature (m-)BDNF with TrkB receptor. Binding of BDNF to TrkB receptor induces its phosphorylation and translocation to cellular membrane. The BDNF/TrkB receptor complex triggers signaling pathways mediated by activation of PI3K, MAPK, PLC-γ, and GTP-ases. All these pathways induced by BDNF cause the enhancement/activation of dendritic growth and branching and growth of neuronal fibers. TrkB: tyrosine kinase B; BDNF: brain derived neurotrophic factor; PI3K: phosphoinositide 3-kinase; Akt: Protein kinase B; PLC: phospholipase C; MAPK: mitogen-activated protein kinase; TrkB: tropomyosin receptor kinase B