fig2

Figure 2. Effect of repeated social defeat (RSD) on IL-1β, CCL2, and CXCL10 protein expression in the brain and liver. C57BL/6J mice (n = 7-12 per group) were subjected to RSD (exposure to a same-sex CD-1 aggressor mouse for 2 h/day for 6 consecutive days); 12 h after the final bout of social defeat, subject mice were then euthanized and tissues were collected and homogenized. Cytokine/chemokine protein expression was measured by ELISA. Data were analyzed by two-way ANOVA followed by pair-wise comparisons and represent mean ± S.E.M.; ^#main effect of sex, p < 0.001; ^@main effect of treatment, P < 0.05; **P < 0.01; ****P < 0.0001