fig5

Figure 5. CD206 immunoreactivity by macrophages but not microglia in ND and AD brain tissue sections. Immunohistochemical localization of CD206 protein using antibody AF2534 (R&D systems). Sections from an ND and AD case are shown: (A) Single-stained section showing strong CD206 immunoreactivity of blood monocyte (purple). Purple represents reaction with nickel-enhanced diaminobenzidine substrate; (B) Single staining of AD section showing immunoreactivity of vascular and perivascular macrophages for CD206. No cells with morphologies of microglia were observed in sections examined. Similar findings observed by other investigators^[122]