REFERENCES
1. Yamauchi T, Kadowaki T. Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases. Int J Obes (Lond) 2008;32:S13-8.
2. Wu MH. Obesity, adiponectin and prognosis of ischemic stroke from bench to beside - basic and clinical studies. Taiwan: National Cheng Kung University; 2017. p. 111.
3. Bloemer J, Pinky PD, Govindarajulu M, Hong H, Judd R, et al. Role of adiponectin in central nervous system disorders. Neural Plast 2018;2018:4593530.
4. Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, et al. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. J Biol Chem 2003;278:9073-85.
5. Waki H, Yamauchi T, Kamon J, Ito Y, Uchida S, et al. Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. J Biol Chem 2003;278:40352-63.
6. Yamauchi T, Kadowaki T. Adiponectin receptor as a key player in healthy longevity and obesity-related diseases. Cell Metab 2013;17:185-96.
7. Waki H, Yamauchi T, Kamon J, Kita S, Ito Y, et al. Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1. Endocrinology 2005;146:790-6.
9. Zhu W, Cheng KK, Vanhoutte PM, Lam KS, Xu A. Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention. Clin Sci (Lond) 2008;114:361-74.
10. Caselli C, D’Amico A, Cabiati M, Prescimone T, Del Ry S, et al. Back to the heart: the protective role of adiponectin. Pharmacol Res 2014;82:9-20.
11. Hui X, Lam KS, Vanhoutte PM, Xu A. Adiponectin and cardiovascular health: an update. Br J Pharmacol 2012;165:574-90.
12. Trujillo ME, Scherer PE. Adiponectin--journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J Intern Med 2005;257:167-75.
13. Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 2004;114:1752-61.
14. Matsuda M, Shimomura I. Roles of adiponectin and oxidative stress in obesity-associated metabolic and cardiovascular diseases. Rev Endocr Metab Disord 2014;15:1-10.
15. Chen MP, Tsai JC, Chung FM, Yang SS, Hsing LL, et al. Hypoadiponectinemia is associated with ischemic cerebrovascular disease. Arterioscler Thromb Vasc Biol 2005;25:821-6.
16. Marousi S, Theodorou G, Karakantza M, Papathanasopoulos P, Ellul J. Serum adiponectin acutely after an ischemic stroke: implications for a long-lasting, suppressed anti-inflammatory role. Acta Neurol Scand 2010;121:277-84.
17. Hossain MM, Mukheem A, Kamarul T. The prevention and treatment of hypoadiponectinemia-associated human diseases by up-regulation of plasma adiponectin. Life Sci 2015;135:55-67.
18. Funahashi T, Matsuzawa Y. Adiponectin and the cardiometabolic syndrome: an epidemiological perspective. Best Pract Res Clin Endocrinol Metab 2014;28:93-106.
19. Nigro E, Scudiero O, Monaco ML, Palmieri A, Mazzarella G, et al. New insight into adiponectin role in obesity and obesity-related diseases. Biomed Res Int 2014;2014:658913.
20. Yatomi K, Miyamoto N, Komine-Kobayashi M, Liu M, Oishi H, et al. Pathophysiological dual action of adiponectin after transient focal ischemia in mouse brain. Brain Res 2009;1297:169-76.
21. Shen LH, Miao J, Zhao YJ, Zhao YJ, Liang W. Expression of brain adiponectin in a murine model of transient cerebral ischemia. Int J Clin Exp Med 2014;7:4590-6.
22. Nishimura M, Izumiya Y, Higuchi A, Shibata R, Qiu J, et al. Adiponectin prevents cerebral ischemic injury through endothelial nitric oxide synthase dependent mechanisms. Circulation 2008;117:216-23.
23. Chen B, Liao WQ, Xu N, Xu H, Wen JY, et al. Adiponectin protects against cerebral ischemia-reperfusion injury through anti-inflammatory action. Brain Res 2009;1273:129-37.
24. Jung YS, Ha SK, Kim SD, Kim SH, Lim DJ, et al. The role of adiponectin in secondary inflammatory reaction in cerebral ischemia. J Cerebrovasc Endovasc Neurosurg 2013;15:171-6.
25. Song W, Huo T, Guo F, Wang H, Wei H, et al. Globular adiponectin elicits neuroprotection by inhibiting NADPH oxidase-mediated oxidative damage in ischemic stroke. Neuroscience 2013;248:136-44.
26. Li X, Guo H, Zhao L, Wang B, Liu H, et al. Adiponectin attenuates NADPH oxidase-mediated oxidative stress and neuronal damage induced by cerebral ischemia-reperfusion injury. Biochim Biophys Acta Mol Basis Dis 2017;1863:3265-76.
27. Wang B, Guo H, Li X, Yue L, Liu H, et al. Adiponectin attenuates oxygen-glucose deprivation-induced mitochondrial oxidative injury and apoptosis in hippocampal HT22 cells via the JAK2/STAT3 pathway. Cell Transplant 2018;27:1731-43.
28. Bai H, Zhao L, Liu H, Guo H, Guo W, et al. Adiponectin confers neuroprotection against cerebral ischemia-reperfusion injury through activating the cAMP/PKA-CREB-BDNF signaling. Brain Res Bull 2018;143:145-54.
29. Song W, Guo F, Zhong H, Liu L, Yang R, et al. Therapeutic window of globular adiponectin against cerebral ischemia in diabetic mice: the role of dynamic alteration of adiponectin/adiponectin receptor expression. Sci Rep 2015;5:17310.
30. Wu MH, Chio CC, Tsai KJ, Chang CP, Lin NK, et al. Obesity exacerbates rat cerebral ischemic injury through enhancing ischemic adiponectin-containing neuronal apoptosis. Mol Neurobiol 2016;53:3702-13.
31. Shen L, Miao J, Yuan F, Zhao Y, Tang Y, et al. Overexpression of adiponectin promotes focal angiogenesis in the mouse brain following middle cerebral artery occlusion. Gene Ther 2013;20:93-101.
32. Miao J, Shen LH, Tang YH, Wang YT, Tao MX, et al. Overexpression of adiponectin improves neurobehavioral outcomes after focal cerebral ischemia in aged mice. CNS Neurosci Ther 2013;19:969-77.