fig1

Figure 1. Magnetic resonance imaging of two patients (Fluid Attenuated Inversion Recovery images). (A) A 38-year-old male with CADASIL and multiple hyperintense lesions. Due to his age, they were initially thought by the radiologist to represent MS. However, anterior temporal lobe lesions prompted genetic testing, revealing the correct diagnosis; (B) The opposite may also occur. This 31-year-old female with the right anterior temporal lesion suffers from relapsing-remitting MS with oligoclonal bands and high IgG index in the CSF. Genetic testing of NOTCH3 was negative. CADASIL: cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy; MS: multiple sclerosis; CSF: cerebrospinal fluid