fig3

Figure 3. In vivo generated PDT-APC vaccine. (1) Intra-cranial inoculation of glioma cells; (2) tumor development, PS injection into the animal; (3) APC (DC/Ma) precursors obtained from donor animal, cultured alone in vitro resulting in naïve APC; (4) iPDT of tumor in situ; (5) immunization with naive APC injection directly into PDT treated tumor. APC: antigen presenting cell; PDT: photodynamic therapy; PS: photosensitizer