fig2

Figure 2. Ex vivo generated PDT-APC vaccine. (1) APC (DC/Ma) precursors obtained from donor animal; (2) cultured alone in vitro resulting in naïve APC; (3) ex vivo PDT treatment of tumor cells; (4) co-culture in vitro of treated tumor cells with naïve APC resulting in activated APC; (5) intra-cranial inoculation of glioma cells into the brain; (6) immunization with activated APC. APC: antigen presenting cell; PDT: photodynamic therapy; PS: photosensitizer