fig4

Figure 4. Effects of acetaminophen (A), p-aminophenol (B), and AM404 (C) on lipopolysaccharide (LPS)-induced cell viability. BV-2 cells were treated with various concentrations of drugs (2, 20, 50 mmol/L) for 15 min, then stimulated with LPS. Following 24 h incubation, cell viability was measured using the MTT assay. Data (mean ± SEM) from 3-5 independent experiments are presented. The effects of the treatments were assessed by the one-way analyses of variance (ANOVA), followed by Dunnett's post hoc test. **P < 0.01, significantly different from stimulated control cells incubated in the absence of drugs. F and P values for the main effects of one-way ANOVA are: (A) F = 6.09, P = 0.018; (B) F = 2.51, P = 0.066; (C) F = 9.39, P = 0.0001