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From: When friend turns foe: central and peripheral neuroinflammation in central nervous system injury
Figure 1. Central and peripheral sources of inflammation. Following CNS injury, such as stroke and TBI, the traditional concept entails a robust inflammatory response within the brain, but equally compelling recent evidence has demonstrated an active inflammatory response, especially from the spleen, contributing to the progression of the disease. Together with other secondary cell death factors, both central and peripheral inflammation exacerbate CNS injury. CNS: central nervous system; TBI: traumatic brain injury
