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![Immune-to-brain signaling and substrates of altered behavior during inflammation](https://image.oaes.cc/df582c9a-0bf2-4b16-ae27-ac2472641437/1427.fig.1.png)
Figure 1. Immune-to-brain signaling pathways involving interleukin-1 in brain circumventricular organs (A), at the blood-brain barrier (B) and peripheral nerves (C) and substrates of altered behavior (D) during peripheral inflammation secondary to infection