fig2

Figure 2. Schematic representation of the adult subventricular zone (SVZ) neurogenic niche. SVZ lines the lateral ventricles and is comprised of three main cell types: the multipotent type B cells that give rise to type C cells (fast dividing transient amplifying cells) that generate type A neuroblasts. Type B cells interact basally with blood vessels and apically with the cerebrospinal fluid (CSF). The composition of the CSF is modified by the choroid plexus, a thin vascularized membrane mainly composed by epithelial cells, which secretes several cytokines and trophic factors to the CSF