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![Neuroinflammation and neurological alterations in chronic liver diseases](https://image.oaes.cc/82480219-9c7c-4c24-8b81-c2bfbc7fb479/1110.fig.1.png)
Figure 1. Hyperammonemia and inflammation act synergistically to induce neurological alterations in chronic liver disease. Chronic liver failure induces both hyperammonemia and peripheral inflammation, leading to microglial activation and neuroinflammation, which alters neurotransmission, leading to cognitive and motor impairment