fig1
![The role of inflammation in cerebral aneurysms](https://image.oaes.cc/8e33f7b3-b022-4f77-9c56-14ee4d21aba4/226.fig.1.png)
Figure 1. (1) Flow-related endothelial injury; (2) triggers an inflammatory response whereby cells (macrophages) infiltrate the arterial wall and secrete pro-inflammatory cytokines and metalloproteinases; (3) the mounting inflammatory response results in proteolytic destruction of the extracellular matrix and smooth muscle cell phenotypic modulation; (4) macroscopically, the arterial wall is remodeled into an aneurysm wall with progressive aneurysmal ballooning