fig6
Figure 6. Treatment of amyloid precursor protein (APP) mice with chlorpyrifos oxon (CPO) results in changes in amyloid β (Aβ)-related biomarkers. Brain Aβ (40) and Aβ (42) (A-β1-40 and Aβ1-42, respectively) levels were determined by enzyme-linked immunosorbent assay. The APP mice (control, corn oil alone) compared to CPO-treated APP mice (CPO) had lower mean brain Aβ (40) levels (a) and mean Aβ (42) levels (b). Brain APP-derived CTF-β, generated by β-secretase, was assessed by western blot analysis (c). Relative quantitation by densitometry showed that the APP mice (control, corn oil alone [CON]) compared with CPO treated APP mice (CPO) had lower mean brain CTF-β levels (d). APP-derived sAPPβ was evaluated by western blot analysis (e). Quantitation by densitometry showed that the APP mice (control, CON) compared to CPO-treated APP mice (CPO) had higher mean brain sAPPβ levels (f) (n = 12 per group, values are expressed as mean ± standard error of the mean, *Statistically significant with P < 0.05)
