fig5

Figure 5. Treatment of amyloid precursor protein (APP) mice with chlorpyrifos oxon (CPO) results in increased brain amyloid plaque load. Amyloid plaque load was determined by immunohistochemistry and image analysis of brain sections from APP mice (control, corn oil alone) and CPO treated APP mice as shown in (a-c and d-f), respectively (representative images). Arrows indicate amyloid plaque deposits. (g) Quantitation showed that control APP mice had mean percent amyloid plaque loads lower than that of the CPO treated mice (n = 12 per group, values are expressed as mean ± standard error of the mean, *Statistically significant with P < 0.05)