fig4

Figure 4. Treatment of amyloid precursor protein (APP) mice with chlorpyrifos oxon (CPO) results in diminished memory retention. The day after the last training session, the submerged platform was removed and the mice were allowed to swim in the pool for 60 s. The percent time each animal swam in the quadrant from which the platform had been removed (northeast [NE] quadrant) (a) and the percent time an animal swam in the annulus of the pool were recorded (b). Greater memory retention is reflected in a higher percent time in the northeast quadrant and lower percent time in the annulus. APP mice (control, corn oil alone) compared to APP mice treated with CPO had percent times in the quadrant of shorter duration. Values are expressed as the mean ± standard error of the mean, and n = 12 per group. *Statistically significant with P < 0.05