fig3

Figure 3. Treatment of amyloid precursor protein (APP) mice with chlorpyrifos oxon CPO results in exacerbated memory deficits. Memory deficits of APP mice were assessed 2 days after completion of the training in the Morris water maze test by measuring the latency period (a) and distance traveled (b) for animals to swim to the submerged, invisible platform. The shorter latency periods and shorter distances traveled indicate improved memory. APP mice (control, corn oil alone) compared to APP mice treated with CPO had shorter mean latency periods. Memory function of wild-type mice of the same strain and age is shown by the dotted line, as reported previously.^[7] Values are expressed as mean ± standard error of the mean, and n = 12 per group. *Statistically significant (P < 0.05)