fig3

From: Increased circulating rather than spinal cytokines accompany chronic pain behaviors in experimental bone cancer and arthritis

Figure 3. Behavioral effects of joint inflammation and bone cancer (n = 18-23, except for von Frey testing where n = 9-13). a: food intake during last week of experiment. b: horizontal exploration of open field. Sessions 1, 2 and 3 correspond to days 1, 4 and 7 after stifle joint injection and days 14, 17 and 20 after femur injection, respectively. c: percentage of paw guarding during rearing against wall. Sessions 1 and 2 correspond to days 2 and 5 after stifle joint injection and days 18 and 21 after femur injection, respectively. d: paw reaction to von Frey filament stimulation on the last day. Statistical differences: *P < 0.05, **P < 0.01 and ***P < 0.001. CFA: complete freund adjuvant; PBS: phosphate buffer saline