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![Chronic inflammation drives glioma growth: cellular and molecular factors responsible for an immunosuppressive microenvironment](https://image.oaes.cc/62be40bb-492d-438d-a92a-fe1e858dc059/77.fig.3.png)
Figure 3. Activation of pro- and anti-inflammatory responses in glioma patients. The flowcharts illustrate (a) the "normal" physiologic processes in the inflammatory response and its resolution; (b) the physiologic processes occurring when glioma-secreted factors influence a state of chronic inflammation resulting in glioma progression; and (c) how rapid glioma growth creates a necrotic/hypoxic environment supporting tumor proliferation and immunosuppression