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Figure 1. (a) Glioma cell proliferation and invasion is negatively affected when T cells recognize tumor-associated antigens resulting in recognition and tumor cell injury that reduces the tumor mass. (b) Mobilization of T regulatory (Treg) cells and myeloid-derived suppressor cells (MDSCs) to the tumor mass, as well as changes in the phenotypes of tumor-associated macrophages (TAM) result in pro-tumorigenic regulation with increases in tumor cell proliferation, angiogenesis, and invasion