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![Targeting glioma stem cells via the Hedgehog signaling pathway](https://image.oaes.cc/7fada2c5-81c2-400e-987d-6ac4d316dfd7/75.fig.1.png)
Figure 1. The off and on states of the Hedgehog (Hh) signaling pathway. Patched (Ptch) inhibits the activity of smoothened, which prevents the suppressor of fused-Gli1/2 complex from entering the nucleus and promotes Gli3 nuclear accumulation, leading to low expression of Hh target genes. Hh binding to Ptch activates the Hh signaling pathway by promoting Gli1/2 expression