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Prof. Le is the Director of the Academic Committee of Medical School of University of Electronic Science and Technology of China, Director of Neurology Department & Institute in Sichuan Academy of Medical Science-Sichuan Provincial Hospital. He also works as life-time Tenured Professor & Head of the top clinical discipline in Dalian Medical University.

From 2006-2013, Dr. Le served as a Professor of Neurology and Director of the Parkinson's Disease Research Center at Baylor College of Medicine, where he was rewarded 3 NIH RO-1. He once worked as the Director of the Institute of Neurology at Shanghai Jiaotong University School of Medicine and the Executive Chairman of the Biomedical Institute of Shanghai Ruijin Hospital, and 100-talent professor of neurogenomic laboratory, Institute of Health Science, Chinese Academy of Science.

Prof. Le interests in the research on pathogenesis, biomarkers and the targeted therapy of neurodegenerative diseases. He has published more than 350 papers in internationally important academic journals, such as Nature Genetics, Science, PNAS, Autophagy, Brain, JAMA, Lancet Neurology, etc. His papers were cited over 38,000 times and he has been chosen into the list of Highly Cited Chinese Researchers in the field of Neuroscience by Elsevier for 9 years (H-index 89). Prof. Le held 3 Key Programs and 6 General Programs of National Natural Science Foundation of China, held/participated in 4 Key Projects of Chinese National Programs for Fundamental Research and Development (973 program) and Chinese National Programs for High Technology Research and Development (863 program).