fig2

Figure 2. Phamerator Comparative Genomics Maps. Comparative genomic maps generated using Phamerator.org for the eight C. acnes phages used in this study. Each genome is arranged along a kilobase ruler with forward transcribed genes marked above the ruler and reverse transcribed genes marked below the ruler. Each gene product is color coded by related protein “phamilies” or “phams” determined by BLASTP and ClustalW as described by Cresawn et al. (2011)^[34]. Phams with known functions are labeled along the Aquarius genome map. Nucleotide sequence similarity based on BLASTN is shown by the shaded regions between genomes, and is colored based on its E value, with violet representing the best matches (lowest E values) and red the worst matches (highest E values). White areas indicate that there is no nucleotide similarity in those regions. As reported for previously studied C. acnes phages, the phages used in this study have genomes with a high degree of synteny and nucleotide conservation, as demonstrated by the mostly violet shading between genomes^[3,6,11].